Focus & calm
DSIP: published research
Also known as Delta sleep-inducing peptide
WAGGDASGE
A nine-amino-acid peptide first isolated in 1977 from the blood of rabbits in deep sleep. It was named for that finding, and research since then has looked at sleep patterns, stress hormones and the body's response to stress.
Evidence at a glance
3 studies 1981–1987
- 1 Human trial
- 1 Animal study
- 1 Review
What researchers look at
- Sleep patterns
- Stress hormones
- Neuropeptides
- Circadian rhythm
What is still unknown
Results across studies have been mixed, and how it works in the body is still not clearly understood.
Studies in people
1- Human trial
In six middle-aged people with chronic insomnia, synthetic DSIP was followed by longer, better-quality sleep with fewer interruptions, without daytime sedation.
Schneider-Helmert D, et al. The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep. Experientia. 1981. PMID 7028502
Animal studies
1- Animal study
In cats, a single dose of synthetic DSIP shortened the time to fall asleep and increased total sleep, mainly deep slow-wave sleep, for about 7 hours.
Susić V, et al. The effects of delta-sleep-inducing peptide (DSIP) on wakefulness and sleep patterns in the cat. Brain Research. 1987. PMID 3620931
Reviews
1- Review
Review describing DSIP as a nine-amino-acid peptide that mainly induced deep (delta) sleep in rabbits, rats, mice and humans, and that occurs naturally in the brain and blood.
Graf MV, et al. Delta-sleep-inducing peptide (DSIP): a review. Neuroscience and Biobehavioral Reviews. 1984. PMID 6145137
Short summaries of published studies, with links to the original papers. Results in animals or cells may not apply to people. This is not medical advice and not a guide to use.